Patient and Public Involvement and Engagement (PPIE) PPIE was been included in all stages of our application for funding. Our lay co-applicants and members of our PPIE group feel the trial is important, have helped design the trial and co-wrote this Plain English Summary. We held two PPIE group meetings with nine people with lived experience of gout flares from the West Midlands, East Midlands and the North West of England. They helped us to decide the outcomes, when the outcomes should be collected, and how long follow-up should be. Our PPIE lead will support all PPIE activities throughout the trial. During the trial, our study team meetings and external advisory group meetings will include public contributors. They will be involved at all stages of the research, including assisting with our ethics application, helping us to understand the results, writing easily understandable messages to explain its findings, and advising us how to publicise the findings widely.